منابع مشابه
Protein-only prions
Bugs to the rescue ugs that live in our gut are not only not harmful but provide signals that maintain gut tissue integrity, according to Seth Rakoff-Nahoum, Ruslan Medzhitov, and colleagues (Yale University, New Haven, CT). The benefits of commensal, or nonpathogenic gut bacteria, are well known. For example, these bacteria digest tricky carbohydrates and supply certain micronutrients. But ina...
متن کاملInfectious Protein Particle Prions
Transmissible spongiform encephalopathies (TSEs), otherwise known as prion disorders, are fatal diseases causing neuro degeneration in a wide range of mammalian hosts, including humans. The causative agent prions are thought to be composed of a rogue isoform of the endogenous prion protein (PrP).Prion diseases or TSEs are a group of rare but fatal neurological disorders that affect humans and a...
متن کاملYeast prions: Inheritance by seeded protein polymerization?
The discovery that RNA enzymes — ribozymes — can fulfill a function previously thought to be the exclusive province of proteins has had far-reaching implications. It has recently become apparent that certain proteins may have the ability to transmit information and to self-replicate, functions normally associated with nucleic acids. The first self-replicating entity proposed to be ‘protein-only...
متن کاملPrions: protein aggregation and infectious diseases.
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative diseases that affect humans and a large variety of animals. The infectious agent responsible for TSEs is the prion, an abnormally folded and aggregated protein that propagates itself by imposing its conformation onto the cellular prion protein (PrPC) of the host. PrPC is necessary for prion replication and ...
متن کاملPrions as protein-based genetic elements.
Fungal prions are fascinating protein-based genetic elements. They alter cellular phenotypes through self-perpetuating changes in protein conformation and are cytoplasmically partitioned from mother cell to daughter. The four prions of Saccharomyces cerevisiae and Podospora anserina affect diverse biological processes: translational termination, nitrogen regulation, inducibility of other prions...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1664rr2